It has been seen that understanding and modifying the polymorphism of an already existing drug creates a scope for the better functioning of that particular drug and plays a crucial role in drug development. The best exhibit of this phenomenon is the HIV drug Ritonavir. The original component used in this drug was less soluble, but the polymorphic form of this drug proved to be less bioavailable. Countries like America, Japan, and the EU Member states generally grant the patent to the pharmaceutical companies even the drug exhibits change in minimal qualities such as stability, solubility, hygroscopicity, etc.
Indian Society for Legal Research 